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SB 431542

(HB3555)
Data

Product overview

  • Name
    SB 431542
  • Short description
    Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells.
  • Biological description

    Potent and selective transforming growth factor β type I receptor (TGF-βRI) actvin receptor-like kinase ALK5, ALK4 and ALK7 inhibitor (IC50 = 94 nM at ALK5).

    Specifically inhibits Smad2/3 activation and blocks TGF-β signal transduction.

    Maintains the undifferentiated state of mouse embryonic stem cells (ESCs).

    Also induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells.

  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide
  • Molecular Weight
    384.4
  • Chemical structure
    SB 431542 [301836-41-9]
  • Molecular Formula
    C22H16N4O3
  • CAS Number
    301836-41-9
  • PubChem identifier
    4521392
  • SMILES
    C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
  • Source
    Synthetic
  • InChi
    InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
  • InChiKey
    FHYUGAJXYORMHI-UHFFFAOYSA-N
  • MDL number
    MFCD11045982
  • Appearance
    Yellow solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100mM) and ethanol (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SB 431542

  • Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.

    Laping et al (2002) Mol Pharmacol 62(1) : 58-64
    PubMedID: 12065755
  • SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.

    Inman et al (2002) Mol Pharmacol 62(1) : 65-74
    PubMedID: 12065756
  • TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells.

    Watabe et al (2003) J Cell Biol 163(6) : 1303-11
    PubMedID: 14676305
  • Mechanism of SB431542 in inhibiting mouse embryonic stem cell differentiation.

    Du et al (2014) Cell Signal 26(10) : 2107-16
    PubMedID: 24949833
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