Akt (PKB) inhibitor. Binds at an allosteric site. Interferes with PH domain-PIP3 binding and enhances Akt ubiquitination. Blocks mTORC1/2, decreases glucose uptake and cell viability. Shows anti-tumor actions.
Good. Happy with the product Verified customer, University of Brighton
Storing and Using Your Product
soluble in DMSO (75mM) or ethanol (75mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for SC 66
Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.Jo H et al (2011) Proc Natl Acad Sci U S A 108(16) : 6486-91.PubMedID: 21464312
AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake.Rashmi R et al (2014) PLoS One 9(4) : e92948.PubMedID: 24705275
Reviews & Product Guides
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