Product overview

  • Name
    SC 66
  • Short description
    Akt inhibitor
  • Biological description
    Akt (PKB) inhibitor. Binds at an allosteric site. Interferes with PH domain-PIP3 binding and enhances Akt ubiquitination. Blocks mTORC1/2, decreases glucose uptake and cell viability. Shows anti-tumor actions.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone
  • Molecular Weight
    276.33
  • Chemical structure
    SC 66  [871361-88-5]
  • Molecular Formula
    C18H16N2O
  • CAS Number
    871361-88-5

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (75mM) or ethanol (75mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SC 66

  • Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.

    Jo H et al (2011) Proc Natl Acad Sci U S A 108(16) : 6486-91.
    PubMedID: 21464312
  • AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake.

    Rashmi R et al (2014) PLoS One 9(4) : e92948.
    PubMedID: 24705275

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