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SCH 23390 hydrochloride


Product overview

  • Name
    SCH 23390 hydrochloride
  • Short description
    Potent, selective D1-like receptor antagonist
  • Biological description
    Potent and selective D1-like receptor antagonist (Ki values are 0.2, 0.3, ~800, ~1100, ~3000 nM at D1, D5, D3, D2 and D4 respectively). Also acts as an agonist at 5-HT1C and 5-HT2C (Ki values are 6.3 and 9.3 respectively). Shows anxiolytic and anticonvulsant effects. Active in vivo.
  • Alternative names
    (R)-(+)-SCH 23390 hydrochloride
  • Biological action
  • Purity
  • Citations


  • Chemical name
    (R)-(+)-7-Chloro-8-hydroxy-3-methyl -1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
  • Molecular Weight
  • Chemical structure
    SCH 23390 hydrochloride  [125941-87-9]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChiKey

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in water (100mM) Soluble in DMSO (100mM) Soluble in ethanol (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SCH 23390 hydrochloride

  • The 'selective' dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin2C receptors.

    Millan MJ et al (2001) Psychopharmacology (Berl) 156(1) : 58-62.
    PubMedID: 11465634
  • SCH 23390: the first selective dopamine D1-like receptor antagonist.

    Bourne JA (2001) CNS Drug Rev 7(4) : 399-414.
    PubMedID: 11830757
  • Selective blockade of dopamine D-1 receptor by SCH 23390 affects dopamine agonist binding to 3H-spiperone labeled D-2 receptors in rat striatum.

    Zhang X et al (1989) Jpn J Pharmacol 50(3) : 333-45.
    PubMedID: 2569545
Our products in action
The following papers have cited the use of SCH 23390 hydrochloride (HB1643) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Dopamine neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons

    Chuhma et al (2018) eLIFE 7:e39786 : DOI: 10.7554/eLife.39786
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