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Product overview

  • Name
    SCH 28080
  • Short description
    Potent, competitive gastric K+ / H+ -ATPase inhibitor
  • Biological description
    Potent and competitive gastric K+ / H+ -ATPase inhibitor (IC50 = 20 nM). Competes against K+ for the K+ recognition site. Able to distinguish different types of ATPases. Displays antiulcer, antisecretory and cytoprotective properties.
  • Biological action
  • Purity
  • Citations



  • Chemical name
  • Molecular Weight
  • Chemical structure
    SCH 28080  [76081-98-6]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in ethanol (10mM) or DMSO (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SCH 28080

  • Gastric antisecretory and cytoprotective activities of SCH 28080.

    Long JF et al (1983) J Pharmacol Exp Ther 226(1) : 114-20.
    PubMedID: 6864535
  • Studies on the mechanism of action of the gastric microsomal (H+ + K+)-ATPase inhibitors SCH 32651 and SCH 28080.

    Scott CK et al (1987) Biochem Pharmacol 36(1) : 97-104.
    PubMedID: 3026407
  • SCH28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K+ access to the ion binding domain.

    Vagin O et al (2002) Biochemistry 41(42) : 12755-62.
    PubMedID: 12379118
Our products in action
The following papers have cited the use of SCH 28080 (HB1124) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.

    Montalbano et al(2015) PLoS One 10(10) : e0140369
    PubMedID: 26460748
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