Product overview

Name SCH 28080
Purity >99%
Description Potent, competitive gastric K+ / H+ -ATPase inhibitor
Write Your Own Review
You're reviewing:SCH 28080
Rate this item:

Images

SCH 28080: Scientist Approved

Biological Data

Biological description Potent and competitive gastric K+ / H+ -ATPase inhibitor (IC50 = 20 nM). Competes against K+ for the K+ recognition site. Able to distinguish different types of ATPases. Displays antiulcer, antisecretory and cytoprotective properties.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in ethanol (10mM) or DMSO (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >99%
Chemical name 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
Molecular Weight 277.33
Chemical structure SCH 28080  [76081-98-6] Chemical Structure
Molecular Formula C17H15N3O
CAS Number 76081-98-6
PubChem identifier 108137
SMILES CC1=C(CC#N)N2C=CC=C(OCC3=CC=CC=C3)C2=N1
InChiKey PYKJFEPAUKAXNN-UHFFFAOYSA-N

References for SCH 28080

References are publications that support the biological activity of the product
  • SCH28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K+ access to the ion binding domain.

    Vagin O et al (2002) Biochemistry 41(42) : 12755-62.
  • Studies on the mechanism of action of the gastric microsomal (H+ + K+)-ATPase inhibitors SCH 32651 and SCH 28080.

    Scott CK et al (1987) Biochem Pharmacol 36(1) : 97-104.
  • Gastric antisecretory and cytoprotective activities of SCH 28080.

    Long JF et al (1983) J Pharmacol Exp Ther 226(1) : 114-20.

3 Item(s)

Publications
These publications cite the use of SCH 28080 purchased from Hello Bio:
  • Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.

    Montalbano et al (2015) PLoS One 10(10) : e0140369
    PubMedID: 26460748

1 Item