SDZ 220-581

(HB0580)

Product overview

  • Name
    SDZ 220-581
  • Short description
    Competitive NMDA receptor antagonist
  • Biological description
    Competitive NMDA receptor antagonist (pKi = 7.7). Blood brain barrier permeable. Decreases prepulse inhibition and increase motor activity. Displays analgesic properties.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (S)-α-Amino-2'-chloro-5-(phosphonomethyl)[1,1'-biphenyl]-3-propanoic acid
  • Molecular Weight
    369.74
  • Chemical structure
    SDZ 220-581  [174575-17-8]
  • Molecular Formula
    C16H17ClNO5P
  • CAS Number
    174575-17-8

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (25mM, gentle warming) or NaOH (100mM, 1.1eq NaOH)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SDZ 220-581

  • Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive NMDA receptor antagonists--II. Pharmacological characterization in vivo.

    Urwyler S et al (1996) Neuropharmacology 35(6) : 655-69.
    PubMedID: 8887975
  • Disruption of prepulse inhibition and increases in locomotor activity by competitive N-methyl-D-aspartate receptor antagonists in rats.

    Bakshi VP et al (1999) J Pharmacol Exp Ther 288(2) : 643-52.
    PubMedID: 9918570
  • Biphenyl-derivatives of 2-amino-7-phosphonoheptanoic acid, a novel class of potent competitive NMDA receptor antagonist--I. Pharmacological characterization in vitro.

    Urwyler S et al (1996) Neuropharmacology 35(6) : 643-54.
    PubMedID: 8887974