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Data

Product overview

  • Name
    Sephin1
  • Short description
    Selective PP1R15A inhibitor
  • Biological description
    Selective inhibitor of the stress-induced Protein Phosphatase 1 Regulatory Subunit 15A (PP1R15A). Guanabenz derivative. Does not bind the related PP1R15B. Protects cells from protein misfolding stress and prevents protein-misfolding diseases such as Charcot-Marie-Tooth 1B and amyotrophic lateral sclerosis in vivo.
  • Alternative names
    NSC65390
  • Biological action
    Inhibitor
  • Purity
    >95%
  • Citations

Properties

  • Chemical name
    (E)-2-(2-Chlorobenzylidene)hydrazinecarboximidamide
  • Molecular Weight
    196.64
  • Chemical structure
    Sephin 1 [951441-04-6]
  • Molecular Formula
    C8H9ClN4
  • CAS Number
    951441-04-6
  • PubChem identifier
    9561611
  • SMILES
    C1=CC=C(C(=C1)/C=N/N=C(N)N)Cl
  • InChi
    InChI=1S/C8H9ClN4/c9-7-4-2-1-3-6(7)5-12-13-8(10)11/h1-5H,(H4,10,11,13)/b12-5+
  • InChiKey
    PDWJALXSRRSUHR-LFYBBSHMSA-N
  • MDL number
    MFCD00790608

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Sephin1

  • Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.

    Das I et al (2015) Science 348(6231) : 239-42
    PubMedID: 25859045
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