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Product overview

  • Name
    SKA 31
  • Short description
    KCa3.1 channel / KCa2 channel subfamily activator
  • Biological description
    KCa3.1 channel (EC50 = 260 nM) and KCa2 subfamily activator (EC50 values are 2.9, 1.9 and 2.9 µM for KCa2.1 KCa2.2 and KCa2.3 channels respectively). Displays vasodilation and antihypertensive properties.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    SKA 31  [40172-65-4]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SKA 31

  • Activation of KCa3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice.

    Radtke J et al (2013) Br J Pharmacol 170(2) : 293-303.
    PubMedID: 23734697
  • Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure.

    Sankaranarayanan A et al (2009) Mol Pharmacol 75(2) : 281-95.
    PubMedID: 18955585
  • SKA-31, a novel activator of SK(Ca) and IK(Ca) channels, increases coronary flow in male and female rat hearts.

    Mishra RC et al (2013) Cardiovasc Res 97(2) : 339-48.
    PubMedID: 23118129
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