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SKF 38393 hydrochloride

(HB6111)
Data

Product overview

  • Name
    SKF 38393 hydrochloride
  • Short description
    Prototypic, selective D1-like receptor partial agonist
  • Biological description

    Prototypic, selective D1-like dopamine receptor partial agonist (Ki values are 1 and ~ 0.5 nM at D1-like receptors (D1 and D5) and ~ 150, ~ 5000 and ~ 1000 nM at D2-like receptors (D2, D3 and D4) respectively). Hydrochloride salt.


    SKF 38393 facilitates long term potentiation (LTP) via D1 and D5 activation and has also been shown to presynaptically stimulate glutamate release in the hippocampus.

    Additionally activates the HPA axis to increase ACTH and corticosterone levels.

    Shows proconvulsant and anorexic effects.

    Blood brain barrier permeable.

    Active in vivo.


    SKF 38393 hydrobromide also available.

  • Alternative names
    SKF38393
  • Biological action
    Agonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrochloride
  • Molecular Weight
    291.77
  • Chemical structure
    SKF 38393 [62717-42-2]
  • Molecular Formula
    C16H17NO2.HCl
  • CAS Number
    62717-42-4
  • PubChem identifier
    147514
  • SMILES
    C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl
  • Source
    Synthetic
  • InChi
    InChI=1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H
  • InChiKey
    YEWHJCLOUYPAOH-UHFFFAOYSA-N
  • MDL number
    MFCD00069248
  • Appearance
    White Solid

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in water (50 mM, warming) and in DMSO (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SKF 38393 hydrochloride

  • Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.

    Sunahara RK et al (1991) Nature 350(6319) : 614-9.
    PubMedID: 1826762
  • The anorectic effect of SK&F 38393, a selective dopamine D1 receptor agonist: a microstructural analysis of feeding and related behaviour.

    Cooper SJ et al (1990) Psychopharmacology (Berl) : 100(2)
    PubMedID: 1968277
  • Effects of quinpirole and SKF 38393 alone and in combination in squirrel monkeys trained to discriminate cocaine.

    Katz JL et al (1992) Psychopharmacology (Berl) 107(2-3) : 217-20.
    PubMedID: 1352052
  • Dopamine receptor pharmacology.

    Seeman and Van Tol (1994) Trends Pharmacol Sci. 15(5) : 264-70
    PubMedID: 7940991
  • D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs.

    Stramiello and Wagner (2008) Neuropharmacology 55(5) : 871-7
    PubMedID: 18644393
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