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SKF 81297 hydrobromide


Product overview

  • Name
    SKF 81297 hydrobromide
  • Short description
    D1-like receptor agonist
  • Biological description
    D1-like receptor agonist (Ki values are 2.2 and >1000 nM at D1 and D2 receptors respectively). Shows ~500 times greater affinity for D1 over D2. Stimulates motor behaviour. Active in vivo.
  • Biological action
  • Purity
  • Customer comments

    SKF81297 hydrobromide is an excellent quality for a fair price. The product had an excellent quality and worked perfectly fine in our experiments. In addition, Hello Bio was the cheapest vendor we could find.Verified customer, MedUni Wien

    Great Product. Compound (SKF 81297 hydrobromide) dissolves into solution easily and produces consistent results. Verified customer, Florida Atlantic University

  • Citations


  • Chemical name
    (±)-6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide
  • Molecular Weight
  • Chemical structure
    SKF 81297 hydrobromide  [67287-39-2]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SKF 81297 hydrobromide

  • Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6

    Yamamoto N et al (2008) Neuroscience 154(3) : 1088-99.
    PubMedID: 18495353
  • Dopamine D1 activation shortens the duration of phases in stereotyped grooming sequences.

    Matell MS et al (2006) Behav Processes 71(2-3) : 241-9.
    PubMedID: 16246504
  • The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys.

    Vermeulen RJ et al (1993) Eur J Pharmacol 235(1) : 143-7.
    PubMedID: 8100193
  • Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys.

    Cai JX et al (1997) J Pharmacol Exp Ther 283(1) : 183-9.
    PubMedID: 9336323
Support & Resources

Reviews & Product Guides


  • Verified customer

    Dissolves Great in Saline. Very easy product to use! Consistent results across studies!
  • Verified customer

    Great Product. Easy to work with. Stays in solution well.
  • Verified customer, Florida Atlantic University

    Great Product. Compound (SKF 81297 hydrobromide) dissolves into solution easily and produces consistent results.
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