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SKF 83566 hydrobromide

(HB1863)
Data

Product overview

  • Name
    SKF 83566 hydrobromide
  • Short description
    Potent, selective D1-like receptor antagonist
  • Biological description
    Potent, selective D1-like receptor antagonist (Ki values are 0.3 and 0.4 nM at D1 and D5 receptors respectively). Also inhibits DAT (IC50 = 5.7 µM) and acts as a selective adenylyl cylase 2 (AC2) inhibitor. Centrally active following systemic administration.
  • Alternative names
    SKF-83566
  • Biological action
    Antagonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide
  • Molecular Weight
    413.15
  • Chemical structure
    SKF 83566 hydrobromide  [108179-91-5]
  • Molecular Formula
    C17H18BrNO.HBr
  • CAS Number
    108179-91-5

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SKF 83566 hydrobromide

  • Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.

    Sunahara RK et al (1991) Nature 350(6319) : 614-9.
    PubMedID: 1826762
  • Locomotor stereotypy produced by dexbenzetimide and scopolamine is reduced by SKF 83566, not sulpiride.

    Fritts ME et al (1998) Pharmacol Biochem Behav 60(3) : 639-44.
    PubMedID: 9678647
  • SKF-83566, a D1-dopamine receptor antagonist, inhibits the dopamine transporter.

    Stouffer MA et al (2011) J Neurochem 118(5) : 714-20.
    PubMedID: 21689106
  • Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.

    Conley JM et al (2013) J Pharmacol Exp Ther 347(2) : 276-87.
    PubMedID: 24008337
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