SKF 89976A hydrochloride

(HB0976)

Product overview

  • Name
    SKF 89976A hydrochloride
  • Short description
    Potent, selective, competitive GAT-1 GABA uptake inhibitor
  • Biological description
    Potent, selective and competitive GAT-1 GABA uptake inhibitor. Selective for GAT-1 over GAT-2, GAT-3 and BGT-1 (IC50 values are 0.13, 550, 944 and 7210 µM respectively). Inhibits GABA uptake (Ki = 7 µM) and transmitter-gated currents (Ki = 0.03 µM). Shows anticonvulsant actions. Blood-brain barrier permeable.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
  • Molecular Weight
    371.91
  • Chemical structure
    SKF 89976A hydrochloride  [85375-15-1]
  • Molecular Formula
    C22H25NO2.HCl
  • CAS Number
    85375-15-1

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    soluble in water (100mM, gentle warming) or DMSO (100mM)

References for SKF 89976A hydrochloride

  • Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1.

    Krause S et al (2005) Mol Pharmacol 68(6) : 1728-35.
    PubMedID: 16150932
  • Orally active and potent inhibitors of gamma-aminobutyric acid uptake.

    Ali FE et al (1985) J Med Chem 28(5) : 653-60.
    PubMedID: 2985785
  • Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats.

    Schwark WS et al (1985) Naunyn Schmiedebergs Arch Pharmacol 329(4) : 367-71.
    PubMedID: 4033806

Reviews & Product Guides