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SKF 89976A hydrochloride


Product overview

  • Name
    SKF 89976A hydrochloride
  • Short description
    Potent, selective, competitive GAT-1 GABA uptake inhibitor
  • Biological description
    Potent, selective and competitive GAT-1 GABA uptake inhibitor. Selective for GAT-1 over GAT-2, GAT-3 and BGT-1 (IC50 values are 0.13, 550, 944 and 7210 µM respectively). Inhibits GABA uptake (Ki = 7 µM) and transmitter-gated currents (Ki = 0.03 µM). Shows anticonvulsant actions. Blood-brain barrier permeable.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
  • Molecular Weight
  • Chemical structure
    SKF 89976A hydrochloride  [85375-15-1]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    soluble in water (100mM, gentle warming) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SKF 89976A hydrochloride

  • Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1.

    Krause S et al (2005) Mol Pharmacol 68(6) : 1728-35.
    PubMedID: 16150932
  • Orally active and potent inhibitors of gamma-aminobutyric acid uptake.

    Ali FE et al (1985) J Med Chem 28(5) : 653-60.
    PubMedID: 2985785
  • Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats.

    Schwark WS et al (1985) Naunyn Schmiedebergs Arch Pharmacol 329(4) : 367-71.
    PubMedID: 4033806
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