Pack	Price	Qty
10mg	$90
50mg	$358

SKF 89976A hydrochloride

(HB0976)

Product overview

Name
SKF 89976A hydrochloride
Short description
Potent, selective, competitive GAT-1 GABA uptake inhibitor
Biological description
Potent, selective and competitive GAT-1 GABA uptake inhibitor. Selective for GAT-1 over GAT-2, GAT-3 and BGT-1 (IC₅₀ values are 0.13, 550, 944 and 7210 µM respectively). Inhibits GABA uptake (K_i = 7 µM) and transmitter-gated currents (K_i = 0.03 µM). Shows anticonvulsant actions. Blood-brain barrier permeable.
Biological action
Inhibitor
Purity
>99%
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Chemical name
1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
Molecular Weight
371.91
Chemical structure
Molecular Formula
C₂₂H₂₅NO₂.HCl
CAS Number
85375-15-1

Storage instructions
+4°C (desiccate)
Solubility overview
soluble in water (100mM, gentle warming) or DMSO (100mM)

Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1.
Krause S et al (2005) Mol Pharmacol 68(6) : 1728-35.
PubMedID: 16150932
Orally active and potent inhibitors of gamma-aminobutyric acid uptake.
Ali FE et al (1985) J Med Chem 28(5) : 653-60.
PubMedID: 2985785
Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats.
Schwark WS et al (1985) Naunyn Schmiedebergs Arch Pharmacol 329(4) : 367-71.
PubMedID: 4033806