SKF 89976A hydrochloride
(HB0976)
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Code: HB0901
Pack: 10mg,50mg,10mM (add 1ml water)
Code: HB0895
Pack: 25mg,50mg,125mg
Code: HB0887
Pack: 10mg,50mg
SKF 89976A hydrochloride
(HB0976)- Data
- Support & Resources
Product overview
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Name
SKF 89976A hydrochloride
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Short description
Potent, selective, competitive GAT-1 GABA uptake inhibitor
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Biological description
Potent, selective and competitive GAT-1 GABA uptake inhibitor. Selective for GAT-1 over GAT-2, GAT-3 and BGT-1 (IC50 values are 0.13, 550, 944 and 7210 µM respectively). Inhibits GABA uptake (Ki = 7 µM) and transmitter-gated currents (Ki = 0.03 µM). Shows anticonvulsant actions. Blood-brain barrier permeable.
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Biological action
Inhibitor
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Purity
>99%
- Citations
Properties
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Chemical name
1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
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Molecular Weight
371.91
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Chemical structure
![SKF 89976A hydrochloride [85375-15-1]](data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs= "SKF 89976A hydrochloride [85375-15-1]")
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Molecular Formula
C22H25NO2.HCl
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CAS Number
85375-15-1
![SKF 89976A hydrochloride [85375-15-1]](https://www.hellobio.com/media/catalog/product/cache/1/image/9df78eab33525d08d6e5fb8d27136e95/h/b/hb0976.png "SKF 89976A hydrochloride [85375-15-1]")
Storing and Using Your Product
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Storage instructions
+4°C (desiccate)
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Solubility overview
soluble in water (100mM, gentle warming) or DMSO (100mM)
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Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for SKF 89976A hydrochloride
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Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1.
Krause S et al (2005) Mol Pharmacol 68(6) : 1728-35.PubMedID: 16150932 -
Orally active and potent inhibitors of gamma-aminobutyric acid uptake.
Ali FE et al (1985) J Med Chem 28(5) : 653-60.PubMedID: 2985785 -
Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats.
Schwark WS et al (1985) Naunyn Schmiedebergs Arch Pharmacol 329(4) : 367-71.PubMedID: 4033806
Reviews & Product Guides
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