SKF 89976A hydrochloride
(HB0976)- Data
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Data
Product overview
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NameSKF 89976A hydrochloride
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Short descriptionPotent, selective, competitive GAT-1 GABA uptake inhibitor
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Biological descriptionPotent, selective and competitive GAT-1 GABA uptake inhibitor. Selective for GAT-1 over GAT-2, GAT-3 and BGT-1 (IC50 values are 0.13, 550, 944 and 7210 µM respectively). Inhibits GABA uptake (Ki = 7 µM) and transmitter-gated currents (Ki = 0.03 µM). Shows anticonvulsant actions. Blood-brain barrier permeable.
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Biological actionInhibitor
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Purity>99%
- Citations
Properties
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Chemical name1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
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Molecular Weight371.91
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Chemical structure
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Molecular FormulaC22H25NO2.HCl
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CAS Number85375-15-1
Storing and Using Your Product
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Storage instructions+4°C (desiccate)
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Solubility overviewsoluble in water (100mM, gentle warming) or DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for SKF 89976A hydrochloride
Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1.
Krause S et al (2005) Mol Pharmacol 68(6) : 1728-35.PubMedID: 16150932Orally active and potent inhibitors of gamma-aminobutyric acid uptake.
Ali FE et al (1985) J Med Chem 28(5) : 653-60.PubMedID: 2985785Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats.
Schwark WS et al (1985) Naunyn Schmiedebergs Arch Pharmacol 329(4) : 367-71.PubMedID: 4033806
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