SKF 89976A hydrochloride

(HB0976)

Pack	Price	Qty
10mg	$90
50mg	$358

(HB0976)

Data

Product overview

Name
SKF 89976A hydrochloride
Short description
Potent, selective, competitive GAT-1 GABA uptake inhibitor
Biological description
Potent, selective and competitive GAT-1 GABA uptake inhibitor. Selective for GAT-1 over GAT-2, GAT-3 and BGT-1 (IC₅₀ values are 0.13, 550, 944 and 7210 µM respectively). Inhibits GABA uptake (K_i = 7 µM) and transmitter-gated currents (K_i = 0.03 µM). Shows anticonvulsant actions. Blood-brain barrier permeable.
Biological action
Inhibitor
Purity
>99%
Citations
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Chemical name
1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
Molecular Weight
371.91
Chemical structure
Molecular Formula
C₂₂H₂₅NO₂.HCl
CAS Number
85375-15-1

Storage instructions
+4°C (desiccate)
Solubility overview
soluble in water (100mM, gentle warming) or DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1.
Krause S et al (2005) Mol Pharmacol 68(6) : 1728-35.
PubMedID: 16150932
Orally active and potent inhibitors of gamma-aminobutyric acid uptake.
Ali FE et al (1985) J Med Chem 28(5) : 653-60.
PubMedID: 2985785
Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats.
Schwark WS et al (1985) Naunyn Schmiedebergs Arch Pharmacol 329(4) : 367-71.
PubMedID: 4033806

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