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SKF 97541


Product overview

  • Name
    SKF 97541
  • Short description
    Potent GABAB receptor agonist
  • Biological description
    Potent GABAB receptor agonist. Evokes hyperpolarizations in septal neurones (EC50 = 50 nM). Shows antidepressant actions. Blood-brain barrier permeable.
  • Biological action
  • Citations


  • Chemical name
    3-Aminopropyl(methyl)phosphinic acid
  • Molecular Weight
  • Chemical structure
    SKF 97541  [127729-35-5]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Solubility overview
    soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SKF 97541

  • Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices.

    Seabrook GR et al (1990) Br J Pharmacol 101(4) : 949-57.
    PubMedID: 1964824
  • Electrophysiological actions of GABAB agonists and antagonists in rat dorso-lateral septal neurones in vitro.

    Bon C et al (1996) Br J Pharmacol 118(4) : 961-7.
    PubMedID: 8799569
  • Effects of GABAB receptor ligands in animal tests of depression and anxiety.

    Frankowska M et al (2007) Pharmacol Rep 59(6) : 645-55.
    PubMedID: 18195453
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