SL327

(HB1350)

Product overview

  • Name
    SL327
  • Short description
    Selective MEK1 and MEK2 inhibitor
  • Biological description
    Selective MEK1 and MEK2 inhibitor (IC50 values are 0.18 and 0.22 µM for MEK1 and MEK2 respectively) which allows selective inhibition of ERK activation. Blocks long term potentiation (LTP) in hippocampal slices in rat CA1. Also disrupts learning and memory and exhibits neuroprotective properties. Blood brain barrier permeable and active in vivo.
  • Alternative names
    SL 327
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
  • Molecular Weight
    335.35
  • Chemical structure
    SL327  [305350-87-2]
  • Molecular Formula
    C16H12F3N3S
  • CAS Number
    305350-87-2
  • PubChem identifier
    9549284
  • SMILES
    C1=CC=C(C(=C1)/C(=C(\N)/SC2=CC=C(C=C2)N)/C#N)C(F)(F)F
  • Source
    Synthetic
  • InChi
    InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
  • InChiKey
    JLOXTZFYJNCPIS-FYWRMAATSA-N
  • MDL number
    MFCD06411432
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in DMSO (100 mM) and in ethanol (50 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SL327

  • Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy.

    Scherle PA et al (2000) J Biol Chem 275(47) : 37086-92.
    PubMedID: 10969080
  • Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis.

    Wang X et al (2003) J Pharmacol Exp Ther 304(1) : 172-8.
    PubMedID: 12490588
  • A necessity for MAP kinase activation in mammalian spatial learning.

    Selcher JC et al (1999) Learn Mem 6(5) : 478-90.
    PubMedID: 10541468

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