Sodium butyrate

(HB1399)

Product overview

  • Name
    Sodium butyrate
  • Short description
    HDAC inhibitor. Directs mESC differentiation into hepatocytes.
  • Biological description
    Histone deacetylase (HDAC) inhibitor (IC50 values are 0.3, 0.3 and 0.4 mM for HDAC1, 7 and 2 respectively). Does not inhibit HDAC6 and HDAC10. Upregulates expression of pluripotency genes in iPSCs and directs mESC differentiation into hepatocytes. Improves cognition and shows anti-Alzheimer's disease and antidepressant actions.
  • Alternative names
    NaB; SB
  • Biological action
    Inhibitor
  • Citations

Properties

  • Chemical name
    Butanoic acid sodium salt
  • Molecular Weight
    110.09
  • Chemical structure
    Sodium butyrate |  [156-54-7]
  • Molecular Formula
    C4H7NaO2
  • CAS Number
    156-54-7

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Sodium butyrate

  • Histone deacetylase is a target of valproic acid-mediated cellular differentiation.

    Gurvich N et al (2004) Cancer Res 64(3) : 1079-86.
    PubMedID: 14871841
  • Sodium butyrate functions as an antidepressant and improves cognition with enhanced neurotrophic expression in models of maternal deprivation and chronic mild stress.

    Valvassori SS et al (2014) Curr Neurovasc Res 11(4) : 359-66.
    PubMedID: 25233278
  • Sodium butyrate efficiently converts fully reprogrammed induced pluripotent stem cells from mouse partially reprogrammed cells.

    Kang SJ et al (2014) Cell Reprogram 16(5) : 345-54.
    PubMedID: 25093667
  • Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression.

    Govindarajan N et al (2011) J Alzheimers Dis 26(1) : 187-97.
    PubMedID: 21593570