Product overview

  • Name
    SP 600125
  • Short description
    Selective, ATP-competitive JNK inhibitor. Prevents BMP9-induced osteogenic MSC differentiation.
  • Biological description
    Selective and reversible ATP-competitive c-Jun N-terminal Kinase (JNK) inhibitor (IC50 values are 40-90 µM at JNK1,2,3). Shows selectivity over a range of other kinases. Dose-dependently inhibits JNK phosphorylation and inhibits gene expression of COX-2, IL-2, IFN-γ and TNF-α. Prevents BMP9-induced osteogenic mesenchymal stem cell (MSC) differentiation. Active in vivo.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    Anthra[1-9-cd]pyrazol-6(2H)-one
  • Molecular Weight
    220.23
  • Chemical structure
    SP 600125
  • Molecular Formula
    C14H8N2O
  • CAS Number
    129-56-6

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (5mM, gentle warming)

References for SP 600125

  • SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase.

    Bennett BL et al (2001) Proc Natl Acad Sci U S A 98(24) : 13681-6.
    PubMedID: 11717429
  • SP600125, a selective JNK inhibitor, protects ischemic renal injury via suppressing the extrinsic pathways of apoptosis.

    Wang Y et al (2007) Life Sci 80(22) : 2067-75.
    PubMedID: 17459422
  • SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase.

    Bennett BL et al (2001) Proc Natl Acad Sci U S A 98(24) : 13681-6.
    PubMedID: 11717429