Product overview

Name SP600125
Purity >98%
Description Selective, ATP-competitive JNK inhibitor. Prevents BMP9-induced osteogenic MSC differentiation. Maintains stem cells in naive pluripotent state.
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Biological Data

Biological description

SP600125 is a selective, cell-permeable, reversible and ATP-competitive JNK (c-Jun N-terminal Kinase) inhibitor (IC50 values are 40-90 µM at JNK1,2,3). SP600125 shows selectivity over a range of other kinases.


SP600125 dose-dependently inhibits phosphorylation of JNK, inhibits expression of the inflammatory genes (COX-2, IL-2, IFN-γ and TNF-α) and prevents apoptosis in many cell types and inhibits autophagy in HeLa cells.


In addition, SP600125 also shows neuronal protective effects and is active in vivo.


SP600125 is also commonly used as a stem cell modulator which prevents BMP9-induced osteogenic mesenchymal stem cells (MSCs) and primary bone marrow stromal cells differentiation and is frequently used in media to maintain stem cells in naive pluripotent state.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (100mM) or ethanol (5mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >98%
Chemical name Anthra[1-9-cd]pyrazol-6(2H)-one
Molecular Weight 220.23
Chemical structure SP 600125 [129-56-6] Chemical Structure
Molecular Formula C14H8N2O
CAS Number 129-56-6
PubChem identifier 8515
SMILES C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O
InChi InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
InChiKey ACPOUJIDANTYHO-UHFFFAOYSA-N
MDL number MFCD00022289
Appearance Yellow solid

References for SP600125

References are publications that support the biological activity of the product
  • Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors

    Abrahamsson et al (2017) Neuron 09 : 030
  • SP600125, a selective JNK inhibitor, protects ischemic renal injury via suppressing the extrinsic pathways of apoptosis.

    Wang Y et al (2007) Life Sci 80(22) : 2067-75.
  • SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase.

    Bennett BL et al (2001) Proc Natl Acad Sci U S A 98(24) : 13681-6.
  • SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase.

    Bennett BL et al (2001) Proc Natl Acad Sci U S A 98(24) : 13681-6.

4 Item(s)

Publications
These publications cite the use of SP600125 purchased from Hello Bio:
  • Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors

    Abrahamsson et al (2017) Neuron 09 : 030
    PubMedID: 29033205

1 Item