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Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in water (1 mg/ml) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical structure |  |
| Molecular Formula | C96H142N26O22 |
| Sequence (one letter) | YAPLPRWSGPIGVSWGLR |
| PubChem identifier | 91826106 |
| SMILES | CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@@H]3CCCN3C(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC5=CC=CC=C54)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CC(C)C)NC(=O)[C@@H]7CCCN7C(=O)[C@H](C)NC(=O)[C@H](CC8=CC=C(C=C8)O)N |
| InChiKey | WMSPWLIEKXALQP-WSSJNERPSA-N |
References for Spadin
References are publications that support the biological activity of the product
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Spadin Modulates Astrocytic Passive Conductance via Inhibition of TWIK-1/TREK-1 Heterodimeric Channels.
Bae Y et al (2020) International journal of molecular sciences 21 : -
The peptidic antidepressant spadin interacts with prefrontal 5-HT(4) and mGluR(2) receptors in the control of serotonergic function.
Moha ou Maati H et al (2016) Brain structure & function 221 : 21-37 -
Spadin as a new antidepressant: absence of TREK-1-related side effects.
Moha Ou Maati H et al (2012) Neuropharmacology 62 : 278-88 -
Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design.
Mazella J et al (2010) PLoS biology 8 : e1000355
Potent TREK-1/ K2P2.1 channel blocker. Shows fast-acting antidepressant effects.
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