Spaglumic acid

(HB0585)

Product overview

  • Name
    Spaglumic acid
  • Short description
    Selective mGlu3 agonist, peptide neurotransmitter
  • Biological description
    Selective mGlu3 receptor agonist and endogenous mammalian peptide neurotransmitter. Blood-brain barrier permeable. Shows anti-allergic actions, potential analgesic and neuroprotective effects. Decreases social withdrawal and motor response in mouse models of schizophrenia.
  • Biological action
    Agonist
  • Purity
    >96%
  • Our products in action

Properties

  • Chemical name
    N-Acetyl-L-aspartyl-L-glutamic acid
  • Molecular Weight
    304.26
  • Chemical structure
    Spaglumic acid  [3106-85-2]
  • Molecular Formula
    C11H16N2O8
  • CAS Number
    3106-85-2
  • PubChem identifier
    91873144
  • SMILES
    CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O.O
  • InChi
    InChI=1S/C11H16N2O8.H2O/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16;/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21);1H2/t6-,7-;/m0./s1
  • InChiKey
    LQMRHOYCEMZABM-LEUCUCNGSA-N
  • MDL number
    MFCD00076652

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Spaglumic acid

  • N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells.

    Wroblewska B et al (1997) J Neurochem 69(1) : 174-81.
    PubMedID: 9202308
  • Comparative efficacy of topical antihistamines in an animal model of early phase allergic conjunctivitis.

    Sanchis-Merino ME et al (2008) Exp Eye Res 86(5) : 791-7.
    PubMedID: 18378229