Product overview

Name Spaglumic acid
Purity >98%
Description Selective mGlu3 agonist, peptide neurotransmitter
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Biological Data

Biological description Selective mGlu3 receptor agonist and endogenous mammalian peptide neurotransmitter. Blood-brain barrier permeable. Shows anti-allergic actions, potential analgesic and neuroprotective effects. Decreases social withdrawal and motor response in mouse models of schizophrenia.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name N-Acetyl-L-aspartyl-L-glutamic acid
Molecular Weight 304.26
Chemical structure Spaglumic acid  [3106-85-2] Chemical Structure
Molecular Formula C11H16N2O8
CAS Number 3106-85-2
PubChem identifier 91873144
SMILES CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O.O
InChi InChI=1S/C11H16N2O8.H2O/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16;/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21);1H2/t6-,7-;/m0./s1
InChiKey LQMRHOYCEMZABM-LEUCUCNGSA-N
MDL number MFCD00076652
Appearance White solid

References for Spaglumic acid

References are publications that support the biological activity of the product
  • Comparative efficacy of topical antihistamines in an animal model of early phase allergic conjunctivitis.

    Sanchis-Merino ME et al (2008) Exp Eye Res 86(5) : 791-7.
  • N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells.

    Wroblewska B et al (1997) J Neurochem 69(1) : 174-81.

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