Spermidine hydrochloride

(HB0586)

Product overview

  • Name
    Spermidine hydrochloride
  • Short description
    nNOS inhibitor / PTPN2 activator
  • Biological description
    Neuronal nitric oxide synthase (nNOS) inhibitor and protein tyrosine phosphatase non-receptor type 2 (PTPN2) activator. Also binds the NMDA polyamine modulatory site. Enhances PCR amplification of DNA and improves efficacy of DNA cleavage. Potential anti-inflammatory properties.
  • Biological action
    Activator
  • Our products in action

Properties

  • Chemical name
    N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride
  • Molecular Weight
    254.63
  • Chemical structure
    Spermidine hydrochloride  [334-50-9]
  • Molecular Formula
    C7H19N3.3HCl
  • CAS Number
    334-50-9
  • PubChem identifier
    9539
  • SMILES
    NCCCNCCCCN.Cl.Cl.Cl

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Spermidine hydrochloride

  • Polyamines inhibit nitric oxide synthase in rat cerebellum.

    Hu J et al (1994) Neurosci Lett 175(1-2) : 41-5.
    PubMedID: 7526294
  • Spermidine facilitates PCR amplification of target DNA.

    Wan CY et al (1993) PCR Methods Appl 3(3) : 208-10.
    PubMedID: 8118404
  • Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis.

    Morón B et al (2013) PLoS One 8(9) : e73703.
    PubMedID: 24040033
  • Effects of polyamines on the binding of [3H]MK-801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site.

    Williams K et al (1989) Mol Pharmacol 36(4) : 575-81.
    PubMedID: 2554112

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