Product overview

Name Spermidine hydrochloride
Description nNOS inhibitor / PTPN2 activator
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Biological Data

Biological description Neuronal nitric oxide synthase (nNOS) inhibitor and protein tyrosine phosphatase non-receptor type 2 (PTPN2) activator. Also binds the NMDA polyamine modulatory site. Enhances PCR amplification of DNA and improves efficacy of DNA cleavage. Potential anti-inflammatory properties.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride
Molecular Weight 254.63
Chemical structure Spermidine hydrochloride  [334-50-9] Chemical Structure
Molecular Formula C7H19N3.3HCl
CAS Number 334-50-9
PubChem identifier 9539
SMILES NCCCNCCCCN.Cl.Cl.Cl
InChiKey LCNBIHVSOPXFMR-UHFFFAOYSA-N

References for Spermidine hydrochloride

References are publications that support the biological activity of the product
  • Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis.

    Morón B et al (2013) PLoS One 8(9) : e73703.
  • Polyamines inhibit nitric oxide synthase in rat cerebellum.

    Hu J et al (1994) Neurosci Lett 175(1-2) : 41-5.
  • Spermidine facilitates PCR amplification of target DNA.

    Wan CY et al (1993) PCR Methods Appl 3(3) : 208-10.
  • Effects of polyamines on the binding of [3H]MK-801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site.

    Williams K et al (1989) Mol Pharmacol 36(4) : 575-81.

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