Product overview

  • Name
    Spermine
  • Short description
    NMDA receptor modulator / ASIC1a channel sensitizer
  • Biological description
    Endogenous polyamine NMDA receptor activity modulator with agonist and antagonist actions. Binds at the polyamine site. Sensitizes ASIC1a channels to acidosis and exacerbates ischemic injury of neurones.
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    N1,N4-Bis(3-aminopropyl)butane-1,4-diamine
  • Molecular Weight
    202.34
  • Chemical structure
    Spermine  [71-44-3]
  • Molecular Formula
    C10H26N4
  • CAS Number
    71-44-3
  • PubChem identifier
    1103
  • SMILES
    NCCCNCCCCNCCCN
  • InChi
    InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
  • InChiKey
    PFNFFQXMRSDOHW-UHFFFAOYSA-N
  • MDL number
    MFCD00008215

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Spermine

  • Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.

    Duan B et al (2011) J Neurosci 31(6) : 2101-12.
    PubMedID: 21307247
  • Polyamines modulate the neurotoxic effects of NMDA in vivo.

    Munir M et al (1993) Brain Res 616(1-2) : 163-70.
    PubMedID: 8358608
  • Interactions of polyamines with ion channels.

    Williams K (1997) Biochem J 325 ( Pt 2) : 289-97.
    PubMedID: 9230104