Product overview

Name Spermine
Purity >99%
Description NMDA receptor modulator / ASIC1a channel sensitizer
Write Your Own Review
You're reviewing:Spermine
Rate this item:

Images

Spermine product vial image | Hello Bio

Biological Data

Biological description Endogenous polyamine NMDA receptor activity modulator with agonist and antagonist actions. Binds at the polyamine site. Sensitizes ASIC1a channels to acidosis and exacerbates ischemic injury of neurones.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >99%
Chemical name N1,N4-Bis(3-aminopropyl)butane-1,4-diamine
Molecular Weight 202.34
Chemical structure Spermine  [71-44-3] Chemical Structure
Molecular Formula C10H26N4
CAS Number 71-44-3
PubChem identifier 1103
SMILES NCCCNCCCCNCCCN
InChi InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChiKey PFNFFQXMRSDOHW-UHFFFAOYSA-N
MDL number MFCD00008215

References for Spermine

References are publications that support the biological activity of the product
  • Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.

    Duan B et al (2011) J Neurosci 31(6) : 2101-12.
  • Interactions of polyamines with ion channels.

    Williams K (1997) Biochem J 325 ( Pt 2) : 289-97.
  • Polyamines modulate the neurotoxic effects of NMDA in vivo.

    Munir M et al (1993) Brain Res 616(1-2) : 163-70.

3 Item(s)

Publications
These publications cite the use of Spermine purchased from Hello Bio:
  • Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors

    Yi F et al (2019) J Physiol 597(22) : 5495-5514
    PubMedID: 31541561
  • Properties of triheteromeric NMDA receptors containing two distinct GluN1 isoforms.

    Yi et al (2018) Mol Pharmacol pii: mol.117.111427 : /mol.117.111427. [Epub ahead of
    PubMedID: 29483146

2 Item(s)