Spiperone hydrochloride

(HB1656)

Product overview

  • Name
    Spiperone hydrochloride
  • Short description
    Selective D2-like receptor antagonist. 5-HT2A antagonist.
  • Biological description
    Selective D2-like receptor antagonist and 5-HT2A antagonist (Ki values are 0.06, 0.6, 0.08, 350 and 35000 at D2, D3, D4, D1 and D5 and 1.27 and >1000 nM at r5-HT2A and r5-HT2C receptors respectively). Also shows activity at 5-HT1A and 5-HT7 receptors. Shows antipsychotic effects. Active in vivo.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride
  • Molecular Weight
    431.94
  • Chemical structure
    Spiperone hydrochloride  [2022-29-9]
  • Molecular Formula
    C23H26FN3O2.HCl
  • CAS Number
    2022-29-9

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Spiperone hydrochloride

  • The D3 dopamine receptor: neurobiology and potential clinical relevance.

    Levant B (1997) Pharmacol Rev 49(3) : 231-52.
    PubMedID: 9311022
  • Neurotransmitters, Drugs and Brain Function

    Webster R (2001) Wiley :
  • Antagonist binding at 5-HT(2A) and 5-HT(2C) receptors in the rabbit: high correlation with the profile for the human receptors.

    Aloyo VJ et al (2000) Eur J Pharmacol 406(2) : 163-9.
    PubMedID: 11020478

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