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Splitomicin

(HB4091)
Data

Product overview

  • Name
    Splitomicin
  • Short description
    Potent,selective, cell permeable yeast NAD+-dependent HDAC Sir2p inhibitor
  • Biological description
    Potent, selective and cell permeable yeast NAD+-dependent histone deacetylase (HDAC) Sir2p inhibitor. Displays higher activity in vivo than in vitro. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. Shown to have diverse effects also in mammalian cells.
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
  • Molecular Weight
    198.2
  • Chemical structure
    Splitomicin [5690-03-9]
  • CAS Number
    5690-03-9
  • InChiKey
    ISFPDBUKMJDAJH-UHFFFAOYSA-N
  • Appearance
    White to off-white solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
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