Product overview

  • Name
    Stattic
  • Short description
    Selective STAT3 inhibitor
  • Biological description
    Selective STAT3 inhibitor. Inhibits STAT3 activation, dimerization and nuclear translocation. Enhances ROS formation. Shows apoptotic and anti-cancer actions.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    6-Nitrobenzo[b]thiophene 1,1-dioxide
  • Molecular Weight
    211.19
  • Chemical structure
    Stattic  [19983-44-9]
  • Molecular Formula
    C8H5NO4S
  • CAS Number
    19983-44-9
  • PubChem identifier
    2779853
  • SMILES
    C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
  • InChi
    InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
  • InChiKey
    ZRRGOUHITGRLBA-UHFFFAOYSA-N
  • MDL number
    MFCD00173799

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Stattic

  • Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.

    Schust J et al (2006) Chem Biol 13(11) : 1235-42.
    PubMedID: 17114005
  • Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma.

    Pan Y et al (2013) PLoS One 8(1) : e54565.
    PubMedID: 23382914
  • The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation.

    Boengler K et al (2013) Curr Pharm Des 19(39) : 6890-5.
    PubMedID: 23590160

Reviews & Product Guides