Staurosporine

(HB0590)

Product overview

  • Name
    Staurosporine
  • Short description
    Potent, non-specific protein kinase inhibitor
  • Biological description
    Potent and non-specific protein kinase inhibitor (IC50 values are 3, 7, 6 and 20 nM at PKC, PKA, p60v-src tyrosine protein kinase and CAMKII respectively). Cell permeable. Induces apoptosis.
  • Alternative names
    AM-2282, STS
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    Antibiotic AM-2282
  • Molecular Weight
    466.53
  • Chemical structure
    Staurosporine  [62996-74-1]
  • Molecular Formula
    C28H26N4O3
  • CAS Number
    62996-74-1
  • PubChem identifier
    44259
  • SMILES
    CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (25mg/ml) or DMF (25mg/ml)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Staurosporine

  • Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.

    Tamaoki T et al (1986) Biochem Biophys Res Commun 135(2) : 397-402.
    PubMedID: 3457562
  • Staurosporine: an effective inhibitor for Ca2+/calmodulin-dependent protein kinase II.

    Yanagihara N et al (1991) J Neurochem 56(1) : 294-8.
    PubMedID: 1846174
  • Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases.

    Rüegg UT et al (1989) Trends Pharmacol Sci 10(6) : 218-20.
    PubMedID: 2672462

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