Stem cell pharmacological tools...low-cost, high quality
Stem cells are unspecialized cells that are capable of self-renewal through mitotic cell division. They may be induced to form more specialized cells by a process termed cellular differentiation.
The main types of stems cells are embryonic stem cells (ESCs) found in blastocysts; adult (or somatic) stem cells, found in adult tissues, induced pluripotent stem cells (iPSCs) and cancer stem cells (CSCs).
Small molecule pharmacological tools can be used to manipulate signalling pathways during the in vitro culture of stem cells. These tools can be used to target signaling pathways that control cell proliferation and differentiation eg. canonical Wnt, transforming growth factor-β (TGF-β) and retinoic acid signaling pathways.
As a specialist supplier of affordable stem cell research tools, Hello Bio has introduced a range of low cost small molecule modulators of stem cell differentiation, de-differentiation, proliferation and stem cell signalling.
Our range includes tools such as ROCK inhibitor Y-27632, which improves survival of human embryonic stem cells undergoing cryopreservation (see our mini review Y-27632 - a ROCK inhibitor with a valuable role in stem cell biology), SB 431542 a TGF-βRI inhibitor which induces proliferation, differentiation and sheet formation of ESC-derived endothelial cells, and DAPT, a γ-secretase inhibitor that induces neuronal differentiation.
Browse our range of small molecule stem cell modulators below:
Our stem cell products are available at low prices - up to 50% less than others suppliers. Take a look at our price comparison table to see for yourself.
Stem cell biology mini-reviews
Check out our new mini-review: The role of small molecules in stem cell biology, and Y-27632 a ROCK inhibitor with a valuable role in stem cell biology.
Featured stem cell products
Y-27632 is a selective p160ROCK inhibitor that improves the survival rate of human embryonic stem cells undergoing cryopreservation. For more information, see our mini review Y-27632 - a ROCK inhibitor with a valuable role in stem cell biology.CHIR 99021 – reprogammes fibroblasts into IPSCs
CHIR 99021 Water-soluble CHIR 99021 trihydrochloride is a highly selective glycogen synthase kinase-3 (GSK-3) inhibitor that enables reprogramming of mouse embryonic fibroblasts into iPS cells.
SB 431542 is a potent and selective inhibitor of TGF-βRI, ALK4 and ALK7 that induces proliferation, differentiation and sheet formation of ESC-derived endothelial cells.