STO-609 acetate

(HB0593)

Order: HB0593

Pack	Price	Qty
10mg	$218

Reviews (1):

(5/5)

(HB0593)

Data

Product overview

Name
STO-609 acetate
Short description
Potent, competitive, selective CaM-KK inhibitor
Biological description
Potent, competitive, selective CaM-KK inhibitor inhibitor (K_i values are 80 and 15 ng/ml for CaM-KKα and CaM-KKβ respectively). Cell-permeable. Shows potential anti-osteoporosis actions.
Biological action
Inhibitor
Purity
>95%
Customer comments

Cheap and quick delivery. Verified customer, Seoul National University
Citations
Submit Your Citation Now

Chemical name
7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate
Molecular Weight
374.35
Chemical structure
Molecular Formula
C₁₉H₁₀N₂O₃.C₂H₄O₂
CAS Number
1173022-21-3
PubChem identifier
16760660
SMILES
CC(=O)O.C1=CC=C2C(=C1)N=C3N2C(=O)C4=CC=CC5=C(C=CC3=C54)C(=O)O
Source
Synthetic
InChi
InChI=1S/C19H10N2O3.C2H4O2/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18;1-2(3)4/h1-9H,(H,23,24);1H3,(H,3,4)
InChiKey
WNRSTFUVBWNELX-UHFFFAOYSA-N
MDL number
MFCD06411456
Appearance
Yellow solid

Storage instructions
Room temperature (desiccate)
Solubility overview
Soluble in 0.1M NaOH/water (45mM), and in DMSO (10mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase.

Tokumitsu H et al (2002) J Biol Chem 277(18) : 15813-8.
PubMedID: 11867640
Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609).

Monteiro P et al (2008) Drug Metab Dispos 36(12) : 2556-63.
PubMedID: 18755850
Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation.

Cary RL et al (2013) J Bone Miner Res 28(7) : 1599-610.
PubMedID: 23408651

Support & Resources

Verified customer, Seoul National University

13/08/2018

Cheap and quick delivery.