STO-609 acetate

(HB0593)

Product overview

  • Name
    STO-609 acetate
  • Short description
    Potent, competitive, selective CaM-KK inhibitor
  • Biological description
    Potent, competitive, selective CaM-KK inhibitor inhibitor (Ki values are 80 and 15 ng/ml for CaM-KKα and CaM-KKβ respectively). Cell-permeable. Shows potential anti-osteoporosis actions.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate
  • Molecular Weight
    374.35
  • Chemical structure
    STO-609 acetate  [1173022-21-3]
  • Molecular Formula
    C19H10N2O3.C2H4O2
  • CAS Number
    1173022-21-3

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Solubility overview
    soluble in NaOH(aq) (45mM) or DMSO (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for STO-609 acetate

  • STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase.

    Tokumitsu H et al (2002) J Biol Chem 277(18) : 15813-8.
    PubMedID: 11867640
  • Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609).

    Monteiro P et al (2008) Drug Metab Dispos 36(12) : 2556-63.
    PubMedID: 18755850
  • Inhibition of Ca2+/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation.

    Cary RL et al (2013) J Bone Miner Res 28(7) : 1599-610.
    PubMedID: 23408651

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