STO-609 acetate
(HB0593)- Data
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Data
Product overview
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NameSTO-609 acetate
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Short descriptionPotent, competitive, selective CaM-KK inhibitor
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Biological descriptionPotent, competitive, selective CaM-KK inhibitor inhibitor (Ki values are 80 and 15 ng/ml for CaM-KKα and CaM-KKβ respectively). Cell-permeable. Shows potential anti-osteoporosis actions.
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Biological actionInhibitor
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Purity>98%
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Properties
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Chemical name7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate
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Molecular Weight374.35
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Chemical structure
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Molecular FormulaC19H10N2O3.C2H4O2
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CAS Number1173022-21-3
Storing and Using Your Product
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Storage instructionsroom temperature (desiccate)
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Solubility overviewsoluble in NaOH(aq) (45mM) or DMSO (10mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for STO-609 acetate
STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase.
Tokumitsu H et al (2002) J Biol Chem 277(18) : 15813-8.PubMedID: 11867640Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609).
Monteiro P et al (2008) Drug Metab Dispos 36(12) : 2556-63.PubMedID: 18755850Inhibition of Ca2+/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation.
Cary RL et al (2013) J Bone Miner Res 28(7) : 1599-610.PubMedID: 23408651
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