Pack	Price	Qty
10mg	$216

STO-609 acetate

(HB0593)

Product overview

Name
STO-609 acetate
Short description
Potent, competitive, selective CaM-KK inhibitor
Biological description
Potent, competitive, selective CaM-KK inhibitor inhibitor (K_i values are 80 and 15 ng/ml for CaM-KKα and CaM-KKβ respectively). Cell-permeable. Shows potential anti-osteoporosis actions.
Biological action
Inhibitor
Purity
>98%
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Chemical name
7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate
Molecular Weight
374.35
Chemical structure
Molecular Formula
C₁₉H₁₀N₂O₃.C₂H₄O₂
CAS Number
1173022-21-3

STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase.
Tokumitsu H et al (2002) J Biol Chem 277(18) : 15813-8.
PubMedID: 11867640
Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609).
Monteiro P et al (2008) Drug Metab Dispos 36(12) : 2556-63.
PubMedID: 18755850
Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation.
Cary RL et al (2013) J Bone Miner Res 28(7) : 1599-610.
PubMedID: 23408651