STO-609 acetate

(HB0593)

Order: HB0593

Pack	Price	Qty
10mg	$216

(HB0593)

Data

Product overview

Name
STO-609 acetate
Short description
Potent, competitive, selective CaM-KK inhibitor
Biological description
Potent, competitive, selective CaM-KK inhibitor inhibitor (K_i values are 80 and 15 ng/ml for CaM-KKα and CaM-KKβ respectively). Cell-permeable. Shows potential anti-osteoporosis actions.
Biological action
Inhibitor
Purity
>98%
Citations
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Chemical name
7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate
Molecular Weight
374.35
Chemical structure
Molecular Formula
C₁₉H₁₀N₂O₃.C₂H₄O₂
CAS Number
1173022-21-3

Storage instructions
room temperature (desiccate)
Solubility overview
soluble in NaOH(aq) (45mM) or DMSO (10mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase.

Tokumitsu H et al (2002) J Biol Chem 277(18) : 15813-8.
PubMedID: 11867640
Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609).

Monteiro P et al (2008) Drug Metab Dispos 36(12) : 2556-63.
PubMedID: 18755850
Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation.

Cary RL et al (2013) J Bone Miner Res 28(7) : 1599-610.
PubMedID: 23408651

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