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Product overview

  • Name
    SU 5402
  • Short description
    Potent FGFR and VEGFR inhibitor. Attenuates integrin β4-induced neural stem cell differentiation.
  • Biological description
    Potent FGFR and VEGFR inhibitor (IC50 values are 0.02, 0.03, 0.51 and >100 µM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Attenuates integrin β4-induced neural stem cell differentiation. Shows potent in vitro and in vivo anticancer activity.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    2-[(1,2-Dihydro-2-oxo-3H-indol-3-yl idene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid
  • Molecular Weight
  • Chemical structure
    SU 5402 |  [215543-92-3]
  • Molecular Formula
  • CAS Number
  • MDL number
  • Appearance
    Light orange to dark orange

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for SU 5402

  • Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.

    Sun et al (1999) J Med Chem 42(25) : 5120-30
    PubMedID: 10602697
  • Neural stem cell differentiation is mediated by integrin beta4 in vitro.

    Su et al (2009) Int J Biochem Cell Biol 41(4) : 916-24
    PubMedID: 18834954
  • Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium.

    Buchholz et al (2013) Stem Cells Transl Med 2(5) : 384-93
    PubMedID: 23599499
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