Product overview

  • Name
    TAK 715
  • Short description
    Potent, p-38 MAP kinase inhibitor. Wnt/β-catenin signaling inhibitor.
  • Biological description
    Potent p-38 MAP kinase inhibitor (IC50 = 7.1 nM for p-38MAPKα). Also Wnt-3a-stimulated β-catenin signalling inhibitor. Shows anti-rheumatic and anti-inflammatory properties.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide
  • Molecular Weight
    399.51
  • Chemical structure
    TAK 715  [303162-79-0]
  • Molecular Formula
    C24H21N3OS
  • CAS Number
    303162-79-0
  • PubChem identifier
    9952773
  • SMILES
    CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for TAK 715

  • Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ε.

    Verkaar F et al (2011) Chem Biol 18(4) : 485-94.
    PubMedID: 21513885
  • Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.

    Miwatashi S et al (2005) J Med Chem 48(19) : 5966-79.
    PubMedID: 16162000
  • X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors.

    Azevedo R et al (2012) Acta Crystallogr D Biol Crystallogr 68(Pt 8) : 1041-50.
    PubMedID: 22868770

Reviews & Product Guides