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Product overview

  • Name
    TAK 715
  • Short description
    Potent, p-38 MAP kinase inhibitor. Wnt/β-catenin signaling inhibitor.
  • Biological description
    Potent p-38 MAP kinase inhibitor (IC50 = 7.1 nM for p-38MAPKα). Also Wnt-3a-stimulated β-catenin signalling inhibitor. Shows anti-rheumatic and anti-inflammatory properties.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    TAK 715  [303162-79-0]
  • Molecular Formula
  • CAS Number
  • PubChem identifier

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for TAK 715

  • Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ε.

    Verkaar F et al (2011) Chem Biol 18(4) : 485-94.
    PubMedID: 21513885
  • Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.

    Miwatashi S et al (2005) J Med Chem 48(19) : 5966-79.
    PubMedID: 16162000
  • X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors.

    Azevedo R et al (2012) Acta Crystallogr D Biol Crystallogr 68(Pt 8) : 1041-50.
    PubMedID: 22868770
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