Tamoxifen Citrate

(HB0602)

Product overview

  • Name
    Tamoxifen Citrate
  • Short description
    Estrogen receptor antagonist/ partial agonist
  • Biological description
    Estrogen receptor antagonist and also partial agonist. Also potent chloride channel HSV-1 inhibitor. Blood brain barrier permeable. Inhibits tumor growth and induces apoptosis in breast cancer cells. Selectively inhibits sterol biosynthesis (IC50 = 1000 nM). Shows neuroprotective potential.
  • Biological action
    Antagonist
  • Purity
    >99%
  • Our products in action

Properties

  • Molecular Weight
    563.7
  • Chemical structure
    Tamoxifen Citrate  [54965-24-1]
  • Molecular Formula
    C32H37NO8
  • CAS Number
    54965-24-1
  • PubChem identifier
    2733525
  • SMILES
    CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in Dimethylsulfoxide (100mM), methanol (50mg/ml, gentle warming) or ethanol (10mg/ml, sonication)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Tamoxifen Citrate

  • Tamoxifen inhibits inward rectifier K+ 2.x family of inward rectifier channels by interfering with phosphatidylinositol 4,5-bisphosphate-channel interactions.

    Ponce-Balbuena D et al (2009) J Pharmacol Exp Ther 331(2) : 563-73.
    PubMedID: 19654266
  • Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase.

    Paul R et al (1998) J Pharmacol Exp Ther 285(3) : 1296-302.
    PubMedID: 9618436
  • Growth inhibition of estrogen receptor-positive and aromatase-positive human breast cancer cells in monolayer and spheroid cultures by letrozole, anastrozole, and tamoxifen.

    Kijima I et al (2005) J Steroid Biochem Mol Biol 97(4) : 360-8.
    PubMedID: 16263272
  • Inhibition of herpes simplex virus type 1 entry by chloride channel inhibitors tamoxifen and NPPB.

    Zheng K et al (2014) Biochem Biophys Res Commun 446(4) : 990-6.
    PubMedID: 24657267

Reviews & Product Guides