Product overview

  • Name
    Tamoxifen
  • Short description
    Estrogen receptor antagonist/ partial agonist
  • Biological description
    Estrogen receptor antagonist and also partial agonist. Also potent chloride channel HSV-1 inhibitor. Blood brain barrier permeable. Inhibits tumor growth and induces apoptosis in breast cancer cells. Selectively inhibits sterol biosynthesis (IC50 = 1000 nM). Shows neuroprotective potential.
  • Biological action
    Antagonist
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine
  • Molecular Weight
    371.52
  • Chemical structure
    Tamoxifen  [10540-29-1]
  • Molecular Formula
    C26H29NO
  • CAS Number
    10540-29-1
  • PubChem identifier
    2733526
  • SMILES
    CC/C(=C(\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3
  • InChi
    InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-
  • InChiKey
    NKANXQFJJICGDU-QPLCGJKRSA-N
  • MDL number
    MFCD00010454

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100mM)

References for Tamoxifen

  • Tamoxifen inhibits inward rectifier K+ 2.x family of inward rectifier channels by interfering with phosphatidylinositol 4,5-bisphosphate-channel interactions.

    Ponce-Balbuena D et al (2009) J Pharmacol Exp Ther 331(2) : 563-73.
    PubMedID: 19654266
  • Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase.

    Paul R et al (1998) J Pharmacol Exp Ther 285(3) : 1296-302.
    PubMedID: 9618436
  • Growth inhibition of estrogen receptor-positive and aromatase-positive human breast cancer cells in monolayer and spheroid cultures by letrozole, anastrozole, and tamoxifen.

    Kijima I et al (2005) J Steroid Biochem Mol Biol 97(4) : 360-8.
    PubMedID: 16263272
  • Inhibition of herpes simplex virus type 1 entry by chloride channel inhibitors tamoxifen and NPPB.

    Zheng K et al (2014) Biochem Biophys Res Commun 446(4) : 990-6.
    PubMedID: 24657267

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