Tautomycin

(HB0603)

Product overview

  • Name
    Tautomycin
  • Short description
    Potent, selective PP1 / PP2A inhibitor
  • Biological description
    Potent and selective protein phosphatase 1 (PP1) and 2A (PP2A) inhibitor (IC50 values are 0.58 and 15 nM respectively). Activates Raf-1 pathway and inhibits GSK-3β. Displays antitumor, antibiotic and antifungal properties.
  • Biological action
    Inhibitor
  • Purity
    >90%
  • Our products in action

Properties

  • Molecular Weight
    766.95
  • Molecular Formula
    C41H66O13
  • CAS Number
    109946-35-2
  • PubChem identifier
    440646
  • SMILES
    C[C@@H]1CC[C@@]2(CC[C@@H]([C@@H](O2)[C@H](C)CC[C@@H]([C@H](C)C(=O)C[C@H]([C@H]([C@@H](C(C)C)OC(=O)C[C@H](C3=C(C(=O)OC3=O)C)O)OC)O)O)C)O[C@H]1CC[C@H](C)C(=O)C

Storing and Using Your Product

  • Solubility overview
    soluble in ethanol or methanol

References for Tautomycin

  • Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway.

    Pinchot SN et al (2009) Am J Surg 197(3) : 313-9.
    PubMedID: 19245907
  • Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity.

    Ju J et al (2009) Org Lett 11(7) : 1639-42.
    PubMedID: 19281218
  • Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta.

    Adler JT et al (2009) Mol Cancer Ther 8(4) : 914-20.
    PubMedID: 19372564

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