Product overview

  • Name
    TC-H 106
  • Short description
    Selective class I HDAC inhibitor
  • Biological description
    Selective class I histone deacetylase (HDAC) inhibitor. Inhibits HDAC1, HDAC3, HDAC2 and HDAC8 (IC50 values are 150, 370, 760 and 5000 nM respectively). Shows slow tight-binding inhibition of HDAC1, 2 and 3. Shows actions against neurodegenerative diseases. Blood-brain barrier permeable.
  • Alternative names
    Histone Deacetylase Inhibitor VII; Pimelic Diphenylamide 106
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    N1-(2-Aminophenyl)-N7-(4-methylphen yl)heptanediamide
  • Molecular Weight
    339.43
  • Chemical structure
    TC-H 106  [937039-45-7]
  • Molecular Formula
    C20H25N3O2
  • CAS Number
    937039-45-7

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (50mM)

References for TC-H 106

  • Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases.

    Chou CJ et al (2008) J Biol Chem 283(51) : 35402-9.
    PubMedID: 18953021
  • Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing.

    Xu C et al (2009) Chem Biol 16(9) : 980-9.
    PubMedID: 19778726
  • HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model.

    Rai M et al (2008) PLoS One 3(4) : e1958.
    PubMedID: 18463734

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