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Code: HB0225
Pack: 1mg,10mg,50mg,100mg,50mM (add 1ml water),100mM (add 1ml water)
Price:$37,$82,$346,$476,$91,$164Selective, competitive NMDA receptor antagonist -
Code: HB0554
Pack: 1mg,10mg,50mg
Price:$43,$91,$382Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs -
Code: HB0443
Pack: 1mg,10mg,50mg,50mM (add 1ml water),100mM (add 1ml water)
Price:$60,$126,$531,$245,$434Potent, selective, competitive AMPA receptor antagonist. Disodium salt.
TCN 201
(HB0604)Product overview
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NameTCN 201
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Short descriptionPotent, non-competitive GluN2A subunit selective NMDA receptor antagonist
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Biological descriptionPotent and non-competitive GluN2A subunit selective NMDA receptor antagonist (pIC50 values are 6.8 and <4.3 for GluN2A and GluN2B respectively in a FLIPR/Ca2+ assay). Binds at allosteric site. Inhibition is GluN1 co-agonist (glycine or D-serine) concentration dependent. Shows anti-nicotine addiction effects.
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Biological actionAntagonist
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Purity>99%
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Our products in action1 citation Submit Your Citation Now
Properties
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Chemical name3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
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Molecular Weight461.89
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Chemical structure
![TCN 201 [852918-02-6]](https://www.hellobio.com/media/catalog/product/cache/1/image/9df78eab33525d08d6e5fb8d27136e95/h/b/hb0604.png "TCN 201 [852918-02-6]")
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Molecular FormulaC21H17ClFN3O4S
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CAS Number852918-02-6
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PubChem identifier4787937
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SMILESC1=CC=C(C=C1)C(=O)NNC(=O)C2=CC=C(C=C2)CNS(=O)(=O)C3=CC(=C(C=C3)F)Cl
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InChiInChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
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InChiKeyFYIBXBFDXNPBSF-UHFFFAOYSA-N
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MDL numberMFCD06683895
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewSoluble in DMSO (100mM)
References for TCN 201
TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.
Edman S et al (2012) Neuropharmacology 63(3) : 441-9.PubMedID: 22579927Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.
Hansen KB et al (2012) J Neurosci 32(18) : 6197-208.PubMedID: 22553026Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.
Bettini E et al (2010) J Pharmacol Exp Ther 335(3) : 636-44.PubMedID: 20810618Reinstatement of nicotine seeking is mediated by glutamatergic plasticity.
Gipson CD et al (2013) Proc Natl Acad Sci U S A 110(22) : 9124-9.PubMedID: 23671067
Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Yi et al(2016) Neuron 91(6) : 1316-29PubMedID: 27618671
