Product overview

  • Name
    TCN 201
  • Short description
    Potent, non-competitive GluN2A subunit selective NMDA receptor antagonist
  • Biological description
    Potent and non-competitive GluN2A subunit selective NMDA receptor antagonist (pIC50 values are 6.8 and <4.3 for GluN2A and GluN2B respectively in a FLIPR/Ca2+ assay). Binds at allosteric site. Inhibition is GluN1 co-agonist (glycine or D-serine) concentration dependent. Shows anti-nicotine addiction effects.
  • Biological action
    Antagonist
  • Purity
    >99%
  • Our products in action

Images

Properties

  • Chemical name
    3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
  • Molecular Weight
    461.89
  • Chemical structure
    TCN 201  [852918-02-6]
  • Molecular Formula
    C21H17ClFN3O4S
  • CAS Number
    852918-02-6
  • PubChem identifier
    4787937
  • SMILES
    C1=CC=C(C=C1)C(=O)NNC(=O)C2=CC=C(C=C2)CNS(=O)(=O)C3=CC(=C(C=C3)F)Cl
  • InChi
    InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
  • InChiKey
    FYIBXBFDXNPBSF-UHFFFAOYSA-N
  • MDL number
    MFCD06683895

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for TCN 201

  • TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.

    Edman S et al (2012) Neuropharmacology 63(3) : 441-9.
    PubMedID: 22579927
  • Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.

    Hansen KB et al (2012) J Neurosci 32(18) : 6197-208.
    PubMedID: 22553026
  • Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.

    Bettini E et al (2010) J Pharmacol Exp Ther 335(3) : 636-44.
    PubMedID: 20810618
  • Reinstatement of nicotine seeking is mediated by glutamatergic plasticity.

    Gipson CD et al (2013) Proc Natl Acad Sci U S A 110(22) : 9124-9.
    PubMedID: 23671067
The following papers have cited the use of TCN 201 (HB0604) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.

    Yi et al(2016) Neuron 91(6) : 1316-29
    PubMedID: 27618671