Product overview

• Name
  TCN 201
• Short description
  Potent, non-competitive GluN2A subunit selective NMDA receptor antagonist
• Biological description
  Potent and non-competitive GluN2A subunit selective NMDA receptor antagonist (pIC₅₀ values are 6.8 and <4.3 for GluN2A and GluN2B respectively in a FLIPR/Ca²⁺ assay). Binds at allosteric site. Inhibition is GluN1 co-agonist (glycine or D-serine) concentration dependent. Shows anti-nicotine addiction effects.
• Biological action
  Antagonist
• Purity
  >99%
• Citations
  1 citation Submit Your Citation Now

Images

Properties

• Chemical name
  3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
• Molecular Weight
  461.89
• Chemical structure
  
• Molecular Formula
  C₂₁H₁₇ClFN₃O₄S
• CAS Number
  852918-02-6
• PubChem identifier
  4787937
• SMILES
  C1=CC=C(C=C1)C(=O)NNC(=O)C2=CC=C(C=C2)CNS(=O)(=O)C3=CC(=C(C=C3)F)Cl
• InChi
  InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
• InChiKey
  FYIBXBFDXNPBSF-UHFFFAOYSA-N
• MDL number
  MFCD06683895

Storing and Using Your Product

• Storage instructions
  +4°C
• Solubility overview
  Soluble in DMSO (100mM)
• Important
  This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.