TCN 201
(HB0604)
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Code: HB0225
Pack: 1mg,10mg,50mg,100mg,50mM (add 1ml water),100mM (add 1ml water)
Code: HB0554
Pack: 1mg,10mg,50mg
Code: HB0443
Pack: 1mg,10mg,50mg,50mM (add 1ml water),100mM (add 1ml water)
TCN 201
(HB0604)- Data
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Product overview
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NameTCN 201
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Short descriptionPotent, non-competitive GluN2A subunit selective NMDA receptor antagonist
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Biological descriptionPotent and non-competitive GluN2A subunit selective NMDA receptor antagonist (pIC50 values are 6.8 and <4.3 for GluN2A and GluN2B respectively in a FLIPR/Ca2+ assay). Binds at allosteric site. Inhibition is GluN1 co-agonist (glycine or D-serine) concentration dependent. Shows anti-nicotine addiction effects.
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Biological actionAntagonist
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Purity>99%
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Citations1 citation Submit Your Citation Now
Images
Properties
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Chemical name3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
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Molecular Weight461.89
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Chemical structure
![TCN 201 [852918-02-6]](data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs= "TCN 201 [852918-02-6]")
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Molecular FormulaC21H17ClFN3O4S
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CAS Number852918-02-6
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PubChem identifier4787937
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SMILESC1=CC=C(C=C1)C(=O)NNC(=O)C2=CC=C(C=C2)CNS(=O)(=O)C3=CC(=C(C=C3)F)Cl
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InChiInChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
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InChiKeyFYIBXBFDXNPBSF-UHFFFAOYSA-N
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MDL numberMFCD06683895
![TCN 201 [852918-02-6]](https://www.hellobio.com/media/catalog/product/cache/1/image/9df78eab33525d08d6e5fb8d27136e95/h/b/hb0604.png "TCN 201 [852918-02-6]")
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewSoluble in DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for TCN 201
TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.
Edman S et al (2012) Neuropharmacology 63(3) : 441-9.PubMedID: 22579927Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.
Hansen KB et al (2012) J Neurosci 32(18) : 6197-208.PubMedID: 22553026Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.
Bettini E et al (2010) J Pharmacol Exp Ther 335(3) : 636-44.PubMedID: 20810618Reinstatement of nicotine seeking is mediated by glutamatergic plasticity.
Gipson CD et al (2013) Proc Natl Acad Sci U S A 110(22) : 9124-9.PubMedID: 23671067
Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Yi et al(2016) Neuron 91(6) : 1316-29PubMedID: 27618671
