TCN 201
(HB0604)- Data
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Data
Product overview
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Name
TCN 201
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Short description
Potent, non-competitive GluN2A subunit selective NMDA receptor antagonist
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Biological description
Potent and non-competitive GluN2A subunit selective NMDA receptor antagonist (pIC50 values are 6.8 and <4.3 for GluN2A and GluN2B respectively in a FLIPR/Ca2+ assay). Binds at allosteric site. Inhibition is GluN1 co-agonist (glycine or D-serine) concentration dependent. Shows anti-nicotine addiction effects.
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Biological action
Antagonist
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Purity
>99%
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Citations
1 citation Submit Your Citation Now
Images
Properties
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Chemical name
3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
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Molecular Weight
461.89
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Chemical structure
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Molecular Formula
C21H17ClFN3O4S
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CAS Number
852918-02-6
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PubChem identifier
4787937
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SMILES
C1=CC=C(C=C1)C(=O)NNC(=O)C2=CC=C(C=C2)CNS(=O)(=O)C3=CC(=C(C=C3)F)Cl
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InChi
InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
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InChiKey
FYIBXBFDXNPBSF-UHFFFAOYSA-N
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MDL number
MFCD06683895
Storing and Using Your Product
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Storage instructions
+4°C
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Solubility overview
Soluble in DMSO (100mM)
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Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for TCN 201
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TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.
Edman S et al (2012) Neuropharmacology 63(3) : 441-9.PubMedID: 22579927 -
Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.
Hansen KB et al (2012) J Neurosci 32(18) : 6197-208.PubMedID: 22553026 -
Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.
Bettini E et al (2010) J Pharmacol Exp Ther 335(3) : 636-44.PubMedID: 20810618 -
Reinstatement of nicotine seeking is mediated by glutamatergic plasticity.
Gipson CD et al (2013) Proc Natl Acad Sci U S A 110(22) : 9124-9.PubMedID: 23671067
Our products in action
The following papers have cited the use of TCN 201 (HB0604) from Hello Bio.
If you have published a paper using this product, and it is not shown here, then please tell us!
We will send you a free gift as a thank you!
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Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Yi et al(2016) Neuron 91(6) : 1316-29PubMedID: 27618671
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