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Product overview

  • Name
    TCN 201
  • Short description
    Potent, non-competitive GluN2A subunit selective NMDA receptor antagonist
  • Biological description
    Potent and non-competitive GluN2A subunit selective NMDA receptor antagonist (pIC50 values are 6.8 and <4.3 for GluN2A and GluN2B respectively in a FLIPR/Ca2+ assay). Binds at allosteric site. Inhibition is GluN1 co-agonist (glycine or D-serine) concentration dependent. Shows anti-nicotine addiction effects.
  • Biological action
  • Purity
  • Citations



  • Chemical name
  • Molecular Weight
  • Chemical structure
    TCN 201  [852918-02-6]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChi
  • InChiKey
  • MDL number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    Soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for TCN 201

  • TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.

    Edman S et al (2012) Neuropharmacology 63(3) : 441-9.
    PubMedID: 22579927
  • Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.

    Hansen KB et al (2012) J Neurosci 32(18) : 6197-208.
    PubMedID: 22553026
  • Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.

    Bettini E et al (2010) J Pharmacol Exp Ther 335(3) : 636-44.
    PubMedID: 20810618
  • Reinstatement of nicotine seeking is mediated by glutamatergic plasticity.

    Gipson CD et al (2013) Proc Natl Acad Sci U S A 110(22) : 9124-9.
    PubMedID: 23671067
Our products in action
The following papers have cited the use of TCN 201 (HB0604) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.

    Yi et al(2016) Neuron 91(6) : 1316-29
    PubMedID: 27618671
  • The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators.

    Sapkota et al(2091) Biochem Pharmacol 159 : 140-153
    PubMedID: 30503374
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