Product overview

  • Name
    TCN 238
  • Short description
    mGlu4 positive allosteric modulator
  • Biological description
    mGlu4 receptor positive allosteric modulator (EC50 = 1 µM). Blood-brain barrier permeable.
  • Biological action
    PAM
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (E)-4-(2-Phenylethenyl)-2-pyrimidinamine
  • Molecular Weight
    197.24
  • Chemical structure
    TCN 238  [125404-04-8]
  • Molecular Formula
    C12H11N3
  • CAS Number
    125404-04-8

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (10mM)

References for TCN 238

  • An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction.

    East SP et al (2010) Bioorg Med Chem Lett 20(16) : 4901-5.
    PubMedID: 20638279