Product overview

Name TCS OX2 29
Purity >98%
Description

Potent and selective orexin OX2 antagonist

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Biological Data

Biological description

Potent, selective orexin-2 receptor antagonist (IC50= 40 nM) which displays >250-fold selectivity for OX2 over OX1 and over 50 other receptors, ion channels and transporters. Shows various biological effects. Active in vivo.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in water (100 mM), and in DMSO (10 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride
Molecular Weight 342.51
Chemical structure TCS OX2 29 [1610882-30-8] Chemical Structure
Molecular Formula C23H31N3O3.2HCl
CAS Number 1610882-30-8
PubChem identifier 10408514
SMILES CC(C)(C)[C@@H](C(=O)N1CCC2=CC(=C(C=C2C1)OC)OC)NCC3=CC=NC=C3
Source Synthetic
InChi InChI=1S/C23H31N3O3/c1-23(2,3)21(25-14-16-6-9-24-10-7-16)22(27)26-11-8-17-12-19(28-4)20(29-5)13-18(17)15-26/h6-7,9-10,12-13,21,25H,8,11,14-15H2,1-5H3/t21-/m1/s1
InChiKey COFVZFLCAOUMJT-OAQYLSRUSA-N
Appearance White solid

References for TCS OX2 29

References are publications that support the biological activity of the product
  • Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats.

    Brown RM et al (2013) The international journal of neuropsychopharmacology 16 : 2067-79
  • Intracerebroventricular injection of orexin-2 receptor antagonist promotes REM sleep.

    Kummangal BA et al (2013) Behavioural brain research 237 : 59-62
  • Involvement of orexin-2 receptors in the ventral tegmental area and nucleus accumbens in the antinociception induced by the lateral hypothalamus stimulation in rats.

    Azhdari-Zarmehri H et al (2013) Peptides 47 : 94-8

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