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Tetrabenazine

(HB1711)
Data

Product overview

  • Name
    Tetrabenazine
  • Short description
    Potent inhibitor of vesicular monoamine transport; depletes 5-HT stores
  • Biological description
    Potent inhibitor of vesicular monoamine uptake; depletes stores of dopamine, serotonin and noradrenalin. Binds with high affinity (IC50= 3.2 nM) to vesicular monoamine transporter (VMAT) in chromaffin granule membranes and displays higher affinity for VMAT2 than VMAT1. Also reported to block dopamine receptors. Causes behavioral depression; inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (3R,11bR)-rel-1,3,4,6,7,11b-hexahyd ro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]qu inolizin-2-one
  • Molecular Weight
    317.2
  • Molecular Formula
    C19H27NO3
  • CAS Number
    58-46-8

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in ethanol (30mM) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
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