Thapsigargin

(HB1118)

Product overview

  • Name
    Thapsigargin
  • Short description
    Potent, non-competitive SERCA inhibitor
  • Biological description
    Potent and non-competitive sarco-endoplasmic Ca2+-ATPase (SERCA) inhibitor. Activates endoplasmic reticulum stress mechanisms. Induces apoptosis in most cells. Shows anticancer and neuroprotective actions.
  • Biological action
    Inhibitor
  • Purity
    >97%
  • Our products in action

Properties

  • Chemical name
    (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b- decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate
  • Molecular Weight
    650.76
  • Chemical structure
    Thapsigargin  [67526-95-8]
  • Molecular Formula
    C34H50O12
  • CAS Number
    67526-95-8
  • PubChem identifier
    446378
  • SMILES
    CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O
  • InChi
    InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
  • InChiKey
    IXFPJGBNCFXKPI-FSIHEZPISA-N
  • MDL number
    MFCD00083511

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in DMSO (100mM)

References for Thapsigargin

  • Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy.

    Zhang X et al (2014) Autophagy 10(10) : 1801-13.
    PubMedID: 25126734
  • Targeting thapsigargin towards tumors.

    Doan NT et al (2014) Steroids :
    PubMedID: 25065587
  • Targeting thapsigargin towards tumors.

    Doan NT et al (2014) Steroids :
    PubMedID: 25065587

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