Topiramate

(HB0618)

Product overview

  • Name
    Topiramate
  • Short description
    Selective GluK1 kainate receptor antagonist
  • Biological description
    Selective GluK1 kainate receptor antagonist (IC50 = 0.46 µM). Also, positive allosteric GABAA receptor modulator and inhibits carbonic anhydrase (Ki values for rat carbonic anhydrase II and IV are 0.1-1 and 0.2 µM respectively). Inhibits L-type Ca2+ and Nav channels (IC50 = 48.9 µM).Shows anticonvulsant activity.
  • Biological action
    Antagonist
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
  • Molecular Weight
    339.36
  • Chemical structure
    Topiramate  [97240-79-4]
  • Molecular Formula
    C12H21NO8S
  • CAS Number
    97240-79-4
  • PubChem identifier
    5284627
  • SMILES
    CC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)C
  • InChi
    InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
  • InChiKey
    KJADKKWYZYXHBB-XBWDGYHZSA-N
  • MDL number
    MFCD00865320

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (100mM) and in ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Topiramate

  • Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells.

    Zona C et al (1997) Neurosci Lett 231(3) : 123-6.
    PubMedID: 9300637
  • Topiramate as an inhibitor of carbonic anhydrase isoenzymes.

    Dodgson SJ et al (2000) Epilepsia 41 Suppl 1 : S35-9.
    PubMedID: 10768298
  • Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons.

    Gryder DS et al (2003) J Neurosci 23(18) : 7069-74.
    PubMedID: 12904467
  • Topiramate modulation of β(1)- and β(3)-homomeric GABA(A) receptors.

    Simeone TA et al (2011) Pharmacol Res 64(1) : 44-52.
    PubMedID: 21421049