Torin 1

(HB2253)

Order: HB2253

Pack	Price	Qty
10mg	$180
50mg	$702

(HB2253)

Data

Product overview

Name
Torin 1
Short description
Potent, selective mTOR inhibitor
Biological description
Potent, selective and ATP-competitive mTOR inhibitor (IC₅₀ vales are 2 and 10 nM at mTORC1 and mTORC2 respectively). Exhibits 1000-fold selecticity for mTOR over PI3K and ~100-fold selectivity when compared to 450 other protein kinases. Impairs cell growth and proliferation to a greater degree than rapamycin.
Biological action
Inhibitor
Purity
>98%
Citations
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Chemical name
1-[4-[4-(1-Oxopropyl)-1-piperazinyl ]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benz o[h]-1,6-naphthyridin-2(1H)-one
Molecular Weight
607.62
Molecular Formula
C₃₅H₂₈F₃N₅O₂
CAS Number
1222998-36-8

Storage instructions
+4°C
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.

Liu et al (2010) J Med CHem 53(19) : 7146-55
PubMedID: 20860370
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

Thoreen et al (2009) J Biol Chem 284(12) : 8023-32
PubMedID: 19150980
Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1.

Francipane and Lagasse (2013) Oncotarget 4(11) : 1948-62
PubMedID: 24185040

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