Torin 1
(HB2253)- Data
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Data
Product overview
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Name
Torin 1
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Short description
Potent, selective mTOR inhibitor
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Biological description
Potent, selective and ATP-competitive mTOR inhibitor (IC50 vales are 2 and 10 nM at mTORC1 and mTORC2 respectively). Exhibits 1000-fold selecticity for mTOR over PI3K and ~100-fold selectivity when compared to 450 other protein kinases. Impairs cell growth and proliferation to a greater degree than rapamycin.
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Biological action
Inhibitor
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Purity
>98%
- Citations
Properties
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Chemical name
1-[4-[4-(1-Oxopropyl)-1-piperazinyl ]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benz o[h]-1,6-naphthyridin-2(1H)-one
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Molecular Weight
607.62
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Molecular Formula
C35H28F3N5O2
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CAS Number
1222998-36-8
Storing and Using Your Product
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Storage instructions
+4°C
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Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Torin 1
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Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.
Liu et al (2010) J Med CHem 53(19) : 7146-55PubMedID: 20860370 -
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.
Thoreen et al (2009) J Biol Chem 284(12) : 8023-32PubMedID: 19150980 -
Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1.
Francipane and Lagasse (2013) Oncotarget 4(11) : 1948-62PubMedID: 24185040
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