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Data

Product overview

  • Name
    Torin 1
  • Short description
    Potent, selective mTOR inhibitor
  • Biological description
    Potent, selective and ATP-competitive mTOR inhibitor (IC50 vales are 2 and 10 nM at mTORC1 and mTORC2 respectively). Exhibits 1000-fold selecticity for mTOR over PI3K and ~100-fold selectivity when compared to 450 other protein kinases. Impairs cell growth and proliferation to a greater degree than rapamycin.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    1-[4-[4-(1-Oxopropyl)-1-piperazinyl ]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benz o[h]-1,6-naphthyridin-2(1H)-one
  • Molecular Weight
    607.62
  • Molecular Formula
    C35H28F3N5O2
  • CAS Number
    1222998-36-8

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Torin 1

  • Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.

    Liu et al (2010) J Med CHem 53(19) : 7146-55
    PubMedID: 20860370
  • An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

    Thoreen et al (2009) J Biol Chem 284(12) : 8023-32
    PubMedID: 19150980
  • Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1.

    Francipane and Lagasse (2013) Oncotarget 4(11) : 1948-62
    PubMedID: 24185040
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