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Data

Product overview

  • Name
    Torin 2
  • Short description
    Potent, selective mTOR inhibitor
  • Biological description
    Potent, selective and ATP-competitive mTOR inhibitor (IC50 = 2.1 nM and EC50 value = 250 pM for inhibition of cellular mTOR activity). Shows 800-fold selectivity over PI3K and >100-fold selectivity over ~400 other protein kinases. Shows potent antiproliferative activity. Causes apoptosis and autophagy and induces G0/G1 cell cycle arrest.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    9-(6-Amino-3-pyridinyl)-1-[3-(trifl uoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H) -one
  • Molecular Weight
    432.4
  • Molecular Formula
    C24H15F3N4O
  • CAS Number
    1223001-51-1
  • PubChem identifier
    51358113
  • SMILES
    O=C(C=C3)N(C5=CC=CC(C(F)(F)F)=C5)C2=C3C=NC1=CC=C(C4=CC=C(N)N=C4)C=C12
  • InChiKey
    GUXXEUUYCAYESJ-UHFFFAOYSA-N

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Torin 2

  • Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation.

    Simioni et al (2014) Oncotarget 5(20) : 10034-47
    PubMedID: 25296981
  • Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.

    Liu et al (2013) Cancer Res 73(8) : 2574-86
    PubMedID: 23436801
  • Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.

    Liu et al (2011) J Med Chem 54(5) : 1473-80
    PubMedID: 21322566
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