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Product overview

  • Name
    TRAM 34
  • Short description
    Potent, selective KCa3.1 channel blocker
  • Biological description
    Potent and selective KCa3.1 channel blocker (IC50 = 18 nM and Kd = 20 nM). Exhibits approx 200 to 1,500-fold less effect at Kv1.1-1.5, Kv3.1, Kv4.2, Kir2.1 and KCa1.1 channels. Displays anti-tumor properties and suppresses T-cell mitogenesis. Blood brain barrier and membrane permeable.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    TRAM 34  [289905-88-0]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (50mM) or ethanol (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for TRAM 34

  • The inhibitor of Ca(2+)-dependent K+ channels TRAM-34 blocks growth of hepatocellular carcinoma cells via downregulation of estrogen receptor alpha mRNA and nuclear factor-kappaB.

    Freise C et al (2013) Invest New Drugs 31(2) : 452-7.
    PubMedID: 23054207
  • The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke.

    Chen YJ et al (2011) J Cereb Blood Flow Metab 31(12) : 2363-74.
    PubMedID: 21750563
  • The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans.

    Toyama K et al (2008) J Clin Invest 118(9) : 3025-37.
    PubMedID: 18688283
  • Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant.

    Wulff H et al (2000) Proc Natl Acad Sci U S A 97(14) : 8151-6.
    PubMedID: 10884437
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