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Tramiprosate

(HB0866)
Data

Product overview

  • Name
    Tramiprosate
  • Short description
    GABA analogue / sGAG mimetic
  • Biological description
    GABA analogue and sulfated glycosaminoglycan (sGAG) mimetic. Shows protective actions against kainic acid convulsive and cytotoxic effects. Blocks PSD95 - nNOS interaction to show neuroprotective effects against ischemic stroke. Also decreases Amyloid-β plaques in Alzheimer's models. Blood-brain barrier permeable.
  • Biological action
    Other
  • Citations

Properties

  • Chemical name
    3-Amino-1-propanesulfonic acid
  • Molecular Weight
    139.17
  • Chemical structure
    Tramiprosate  [3687-18-1]
  • Molecular Formula
    C3H9NO3S
  • CAS Number
    3687-18-1

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Tramiprosate

  • Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS.

    Wu S et al (2014) Neuropharmacology 83 : 107-17.
    PubMedID: 24769446
  • Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid.

    Fariello RG et al (1982) Neurology 32(3) : 241-5.
    PubMedID: 7199633
  • Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis.

    Gervais F et al (2007) Neurobiol Aging 28(4) : 537-47.
    PubMedID: 16675063
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