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Tramiprosate

(HB0866)
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Technical documents: CoA Datasheet

Product overview

Name Tramiprosate
Alternative names Homotaurine
Description GABA analogue / sGAG mimetic
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description GABA analogue and sulfated glycosaminoglycan (sGAG) mimetic. Shows protective actions against kainic acid convulsive and cytotoxic effects. Blocks PSD95 - nNOS interaction to show neuroprotective effects against ischemic stroke. Also decreases Amyloid-β plaques in Alzheimer's models. Blood-brain barrier permeable.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 3-Amino-1-propanesulfonic acid
Molecular Weight 139.17
Chemical structure Tramiprosate [3687-18-1] Chemical Structure
Molecular Formula C3H9NO3S
CAS Number 3687-18-1
PubChem identifier 1646
SMILES NCCCS(=O)(O)=O
InChiKey SNKZJIOFVMKAOJ-UHFFFAOYSA-N

References for Tramiprosate

References are publications that support the biological activity of the product

  • Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS.

    Wu S et al (2014) Neuropharmacology 83 : 107-17.
    Read more (PubMedID: 24769446)

  • Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis.

    Gervais F et al (2007) Neurobiol Aging 28(4) : 537-47.
    Read more (PubMedID: 16675063)

  • Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid.

    Fariello RG et al (1982) Neurology 32(3) : 241-5.
    Read more (PubMedID: 7199633)

3 Item(s)

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Order: HB0866
Pack PriceQty
1g
$41
GABA analogue / sGAG mimetic
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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