Tranilast

(HB1201)

Product overview

  • Name
    Tranilast
  • Short description
    TRPV2 channel inhibitor. Potent mast cell stabilizer.
  • Biological description
    TRPV2 channel inhibitor and potent mast cell stabilizer. Also inhibits angiotensin-II induced contractions (IC50 = 36 µM). Inhibits reactive oxygen species, cytokines, leukotrienes and prostaglandin release. Displays antiallergic, antiapoptotic and anti-inflammatory properties. Blood brain barrier permeable.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid
  • Molecular Weight
    327.34
  • Chemical structure
    Tranilast  [53902-12-8]
  • Molecular Formula
    C18H17NO5
  • CAS Number
    53902-12-8
  • PubChem identifier
    5282230
  • SMILES
    COC1=C(C=C(C=C1)/C=C/C(=O)NC2=CC=CC=C2C(=O)O)OC
  • InChi
    InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
  • InChiKey
    NZHGWWWHIYHZNX-CSKARUKUSA-N
  • MDL number
    MFCD00864787

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Tranilast

  • Tranilast increases vasodilator response to acetylcholine in rat mesenteric resistance arteries through increased EDHF participation.

    Xavier FE et al (2014) PLoS One 9(7) : e100356.
    PubMedID: 24992476
  • Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II.

    Jin D et al (1998) Eur J Pharmacol 361(2-3) : 199-205.
    PubMedID: 9865509
  • Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells.

    Hisanaga E et al (2009) Diabetes 58(1) : 174-84.
    PubMedID: 18984736
  • Tranilast binds to aβ monomers and promotes aβ fibrillation.

    Connors CR et al (2013) Biochemistry 52(23) : 3995-4002.
    PubMedID: 23679559

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