Tranylcypromine hydrochloride

(HB1412)

Product overview

  • Name
    Tranylcypromine hydrochloride
  • Short description
    LSD1 / MAO inhibitor. Enables reprogramming of mouse embryonic fibroblasts into iPS cells.
  • Biological description
    Lysine-specific demethylase 1 (LSD1) and monoamine oxidase (MAO) inhibitor (IC50 = < 2 µM for LSD1). Irreversible inhibition of LSD1, inhibits H3K4 demethylation. Enables reprogramming of mouse embryonic fibroblasts into iPS cells. Shows antidepressant actions.
  • Alternative names
    trans-2-phenylcyclopropylamine; 2-PCPA; Parnate
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (±)-trans-2-Phenylcyclopropylamine hydrochloride
  • Molecular Weight
    169.65
  • Chemical structure
    Tranylcypromine hydrochloride  [1986-47-6]
  • Molecular Formula
    C9H11N.HCl
  • CAS Number
    1986-47-6

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Solubility overview
    soluble in water (100mM) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Tranylcypromine hydrochloride

  • trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.

    Schmidt DM et al (2007) Biochemistry 46(14) : 4408-16.
    PubMedID: 17367163
  • Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications.

    Lee MG et al (2006) Chem Biol 13(6) : 563-7.
    PubMedID: 16793513
  • Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.

    Li W et al (2009) Stem Cells 27(12) : 2992-3000.
    PubMedID: 19839055
  • Tranylcypromine: new perspectives on an 'old' drug.

    Frieling H et al (2006) Eur Arch Psychiatry Clin Neurosci 256(5) : 268-73.
    PubMedID: 16927039