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Biological Data
Biological description | Lysine-specific demethylase 1 (LSD1) and monoamine oxidase (MAO) inhibitor (IC50 = < 2 µM for LSD1). Irreversible inhibition of LSD1, inhibits H3K4 demethylation. Enables reprogramming of mouse embryonic fibroblasts into iPS cells. Shows antidepressant actions. |
Solubility & Handling
Storage instructions | room temperature (desiccate) |
Solubility overview | Soluble in water (100mM) or DMSO (100mM) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | (±)-trans-2-Phenylcyclopropylamine hydrochloride |
Chemical structure | |
Molecular Formula | C9H11N.HCl |
PubChem identifier | 2723716 |
SMILES | N[C@H]1[C@H]([C@]2=CC=CC=C2)C1.Cl |
InChiKey | ZPEFMSTTZXJOTM-OULXEKPRSA-N |
References for Tranylcypromine hydrochloride
References are publications that support the biological activity of the product
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Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.
Li W et al (2009) Stem Cells 27(12) : 2992-3000. -
trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.
Schmidt DM et al (2007) Biochemistry 46(14) : 4408-16. -
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications.
Lee MG et al (2006) Chem Biol 13(6) : 563-7. -
Tranylcypromine: new perspectives on an 'old' drug.
Frieling H et al (2006) Eur Arch Psychiatry Clin Neurosci 256(5) : 268-73.
LSD1 / MAO inhibitor. Enables reprogramming of mouse embryonic fibroblasts into iPS cells.