Trichostatin A

(HB1402)

Product overview

  • Name
    Trichostatin A
  • Short description
    Potent HDAC inhibitor. Induces hiPSCs differentiation to cardiogenic cells.
  • Biological description
    Potent histone deacetylase (HDAC) inhibitor. Inhibits HDAC1, 3, 2, 6, 8 and 5 (IC50 values are 0.4, 1, 1.3, 2, 90 and 520 nM respectively). Shows anti-proliferative and anti-cancer actions.
  • Alternative names
    TSA
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (2E,4E,6R)-7-(4-(Dimethylamino)phen yl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamid e
  • Molecular Weight
    302.37
  • Chemical structure
    Trichostatin A  [58880-19-6]
  • Molecular Formula
    C17H22N2O3
  • CAS Number
    58880-19-6
  • PubChem identifier
    444732
  • SMILES
    C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
  • InChi
    InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
  • InChiKey
    RTKIYFITIVXBLE-QEQCGCAPSA-N
  • MDL number
    MFCD03848392

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in DMSO (50mM) and in ethanol (10mM)

References for Trichostatin A

  • Synapse microarray identification of small molecules that enhance synaptogenesis.

    Shi P et al (2011) Nat Commun 2 : 510
    PubMedID: 22027590
  • Inhibition of mitogenesis in Balb/c-3T3 cells by Trichostatin A. Multiple alterations in the induction and activation of cyclin-cyclin-dependent kinase complexes.

    Wharton W et al (2000) J Biol Chem 275(43) : 33981-7.
    PubMedID: 10945992
  • Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo.

    Vigushin DM et al (2001) Clin Cancer Res 7(4) : 971-6.
    PubMedID: 11309348